She's featured in the Fallout: New Vegas add-on Dead Money (released December 21, 2010).
Slowly revealed through the course of the game is that she owes her career to singer Dean Domino, who plucked her from obscurity and groomed her. Then he introduced her to wealthy businessman Frederick Sinclair, blackmailing her with her "chem use, indiscretions" to get Sinclair to fall in love with her. Then Domino would use his access via Keyes to rob Sinclair's Sierra Madre casino. Her drug uses turns out to be because she is suffering a painful terminal illness.
A poster for her film, Love Sets Sail hangs in the resort.
Keyes, Dean Domino, and Joey Baxter were to perform at the Tampico Theater in the Sierra Madre resort for it's gala opening event, but that turned out to be the day World War III started, ending civilization.
"Vera Keyes" is revealed to only be her stage name, but her real name is never given.
- "Begin Again," performed by Stephanie Dowling and Justin Bell, lyrics by Mikey Dowling and Chris Avellone.
- "Let the Bright Tomorrow In"
- "Go to the Faraway"