Joanie and the Slashettes
In the two-part Married with Children episode "Kelly Does Hollywood" (Part I aired November 10, 1991; Part II aired November 17, 1991), teen Kelly Bundy (Christina Applegate) gets her Chicago public access trash-talking discussion show, Vital Social Issues 'n' Stuff with Kelly picked up by a network.
Her network show's house band is this trio of leather-clad, guitar wielding rock chicks who sing a song whose entire lyric is "sex." Later, the network ruins the show by remaking it into 1950s niceness and the band is transformed into Joanie and the Hepcats, whose single-word song is now "milk!"
Then the show gets cancelled. Alas, not lowbrow Fox sitcom Married With Children, but Vital Social Issues 'n' Stuff with Kelly.